ये पुरुषाः those men, कालपाशपरिक्षिप्ताः bound by the noose of death, भवन्ति remain, ते you, निरस्तषडिन्द्रियाः whose six senses (five sense organs and mind) cease to function, कार्याकार्यम् (sense of discrimination) of what to and not to do, न जानन्ति do not know.

Those bound by the noose of death, do not know what to and what not to do, as their six senses cease to function.